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ISSN (Print) 1013-9052
EISSN 1658-3558
The Saudi Dental Journal,
P.O. Box 52500,
Riyadh 11563,
Kingdom of Saudi Arabia
P.O. Box 52500,
Riyadh 11563,
Kingdom of Saudi Arabia
| Tel. |
966-1-467-7328 |
| Fax. |
933-1-467-7308 / 966-1-467-7534 |
| Email |
saudidj@ksu.edu.sa |
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Expression of beta-2-microglobulin by normal, benign and malignant Oral Epithelia
A.H.M. Shabana, BDS, MSc, PhD*
Beta-2-microglobulin is a cell surface protein that plays an important role in cell-cell recognition and interactions. The cell expression of this protein was investigated on both normal and pathological oral epithelia using immunohistochemical methods. In normal and benign reactive epithelia, beta-2 microglobulin was detected at the cell surface. In contrast, carcinoma cells and the associated non-malignant surface epithelial cells showed aberrant expression of beta-2-microglobulin in the form of cytoplasmic localization and depletion at the cell membrane. This localization indicated that these cells maintained the synthesis of the protein. The depletion from the cell surface might be due to masking by receptors such as viruses or autoantibodies. The absence of detectable surface beta-2- microglobulin might be a mechanism by which the malignant cell escapes the immune surveillance.
Saudi Dental Journal 1991;3(3):92-98.
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