1992-4-1-4-10 - Saudi Dental Journal

ISSN (Print) 1013-9052
EISSN 1658-3558

The Saudi Dental Journal,
P.O. Box 52500,
Riyadh 11563,
Kingdom of Saudi Arabia

Tel.	966-1-467-7328
Fax.	933-1-467-7308 / 966-1-467-7534
Email	saudidj@ksu.edu.sa

The effect of Benzylisothfocyanate on epithelial changes

induced by trauma and DMBA in the hamster tongue

A.M. AlDosari, BDS, MSD, PhD*, A.H. Kafrawy, BDS, MSD;**
S.M. Standish, DDS, MSD**
* King Saud University, College of Dentistry, Riyadh, Saudi Arabia.
** Indiana University, School of Dentistry, IN, USA.

The purpose of this study was to investigate the effect of benzylisothiocyanate (BIT) on the epithelial changes induced by trauma and dimethylbenzanthracin (DMBA). Eighty male Syrian golden hamsters, five weeks old, were randomly divided into four groups. Croup I received repeated trauma and mineral oil painting to the middle third of the right lateral border of the tongue. Croup II was traumatized in the same way as Group I and received painting of the wound with BIT. Croup III received similar trauma and painting of the wound with DMBA. Group IV received trauma plus DMBA and BIT painting in alternate dose.

Gross findings showed reduction in the development of persistent ulcers and papillary lesions in the animals that received BIT painting. Microscopic examination revealed epithelial changes ranging from mild dysplasia to invasive carcinoma in all animals. In Groups II and IV, fewer animals showed these changes, and the carcinomas seen in the two groups tended to be well differentiated when compared to the others.

The results indicated that BIT retarded the development of neoplastic changes induced by trauma or trauma plus DMBA

Saudi Dental Journal 1992;4(1):4-10.