036.
Assessment of lipid profile among type 2 diabetic and non-diabetic
periodontal patients
Dr. DALAL H. AL-OTAIBI
Division of Periodontics, Department of Preventive
Dental Sciences, College of Dentistry, King Saud University , Riyadh, Saudi
Arabia
The objectives of the study are two-folds: first, to
evaluate the extent/severity of periodontal disease in diabetic and non
diabetic periodontally involved patients and second, to study the dyslipidemia
in diabetic and periodontitis patients. A total of ninety patients were
recruited and divided into three equal groups of 30 subjects with age and
gender matched and divided as follows: Group I (healthy group): Periodontally
and systemically healthy subjects. Group II (periodontitis group): Chronic
periodontitis patients with no systemic disease. Group III (diabetic group):
Chronic periodontitis patients with type 2 diabetes mellitus. Plaque index
(PI), bleeding on probing (BOP), probing pocket depth (PPD) and clinical
attachment level (CAL)
were measured at the time of initial examination. The glycated hemoglobin
(HBA1c), total cholesterol, low density lipoprotein (LDL), triglyceride, high
density lipoprotein (HDL) and lipoprotein (a) were also measured. The results
showed significantly higher value of the periodontal parameters (PD and CAL) in
diabetic patients when compared to the periodontitis patients. The total
cholesterol, low density lipoprotein (LDL), triglyceride, and lipoprotein (a)
were also found to be significantly higher among the periodontitis patients
than the healthy subjects. This study indicated that type 2 diabetic patients
had a higher risk to develop advanced periodontal disease than the non-diabetic
subjects. It also highlighted the association of dyslipidemia in periodontitis
patients.
Saudi Dental Journal
2007;19(SI)-Abstr.036
037.
Hyperglycemia and oral
mucosal lesions among diabetic patients in Jeddah City
Dr. SOLIMAN O.
AMRO* Dr. SAFIA AL-ATTAS**
*Associate
Professor, **Assistant Professor, Oral Basic and Clinical Sciences, Faculty of
Dentistry, King Abdulaziz
University, Jeddah, Saudi Arabia
Objective: To determine the prevalence of
oral mucosal lesions in diabetic patients and its association with glycemic
control.
Methods: The study comprised 152 diabetic
patient (101 = type 2, 51 = type 1) attending KAAUH diabetic clinic and 50 sex
and aged matched non diabetic controls. Measurements of total HbA1c was
performed in diabetics to determine the level of glycemic control and random
blood glucose was measured for control group selection. A complete intraoral
soft tissue examination was performed according to the World Health
Organization guidelines. Abnormalities were recorded on a checklist of common
oral lesions. The relation between HbA1c concentration and prevalence of oral
mucosal lesions were analyzed.
Results: The prevalence of one or more oral
mucosal lesions in the diabetic sample was significantly higher than non
diabetics. The most frequent lesions among diabetic patient were fissured and
burning tongue sensation, followed by taste disturbance and xerostomia.
Logistic regression model revealed that xerostomia increased the probability of
one or more oral lesions, while age, gender, smoking, medication use, education
and social factors had no effect. We have found no correlation between the
quality of gylcemic control and frequency of oral mucosal lesions.
Conclusion: We can conclude that oral mucosal
lesions are common among diabetic patient in Jeddah city, suggesting the
necessity for improved standard of prevention, diagnostic and opportune
treatment of these lesions.
Saudi Dental Journal
2007;19(SI)-Abstr.037
038.
Molecular
characterization of candida species in patients with mucosal disease
Dr. ZUBAIDA M. AL-KARAAWI*, Dr. M.J.
MCCULLOUGH**, Dr. M. MANFREDI***, Dr. S.R. PORTER‡
*Riyadh Armed Forces
Hospital, Riyadh,
Saudi Arabia,**School of Dental
Sciences, University of Melbourne, Australia, ***Oral Medicine Department, University of Parma, Italy,
‡Eastman Dental Institute of Oral Health Care Sciences, UCL, London
Aim: To assess the prevalence, species, molecular characterization of
Candida present in the oral cavity of patients diagnosed with oral mucosal
disease.
Materials and Methods: Fifty patients with mucosal abnormalities and 60 healthy
subjects enrolled in this study. Oral swills were collected and Candida
isolates were identified by phenotypic and genotypic methods. Each isolate was
genotyped into subgroups via the presence and size of transposable instron of
the 25S rDNA. The in vitro adhesion,
production of aspartyl proteinase and susceptibility to fluconazole of all
isolates were assessed.
Results: There were no differences in Candida carriage (P = 0.17) nor Candida
colonization (cfu/ml ¡Ý 100) (P = 0.97) between the two groups of patients.
However, non-albicans Candida was significantly more common in the diseased
patients (6/33) than the controls (1/25) (P = 0.03). There were no differences
in Candida albicans genotypes between diseased and control subjects (P = 0.17).
There was no significant difference in the proteinase activity (P = 0.97), in vitroin vitro susceptibility to fluconazole
(P = 0.55) between the diseased and healthy subjects.
Conclusion: The present results support the concept that patients with
oral mucosal disease are not at increased risk of Candida colonization,
virulence, or infection than that of the healthy subjects.
Saudi Dental Journal
2007;19(SI)-Abstr.038
039.
Mercuric
chloride induces IL-6 and IL-8 production in a stratified oral mucosal model
Dr. NAVEED A. KHAWAJA
Specialist
and Registrar, Department of Maxillofacial Surgery and Diagnostic Sciences, College
of Dentistry, King Saud University , Riyadh, Saudi Arabia
Oral lichen planus is chronic inflammatory and
cell mediated muco-cutaneous lesion. It appears as either white reticular;
plaque, or erosive lesions with T-lymphocyte response to stimuli immediately
underlying connective tissue. The same type of lesion also occurs in contact to
dental materials and other antigen in oral mucosa.
In susceptible individuals, oral lichenoid
reaction may develop on mucosal surfaces contacting amalgam restorations. The
mechanism is not clear for this, although recently it has been reported that
HgCl2 induces IL-8 production in oral keratinocyte cultures. However, this
study was limited as the monolayer culture used, does not replicate the
stratified squamous nature of oral epithelium.
In this study, cultured model oral mucosa was
used to investigate the effect of HgCl2 and to see if it induced cytokine /
chemokine production. These changes could play a role in the initiation of oral
lichenoid reactions.
Mucosal model cultures were exposed to different
quantity of mercuric chloride at different times. Tissue viability was assessed
and morphological examination. Cellular and secreted levels of cytokines were
quantified by sandwich ELISA.
Saudi Dental Journal
2007;19(SI)-Abstr.039
040.
Autogenous
bone graft for implant site preparation
Dr. AIMAN OTHMAN JOHAR
Assistant
Professor and Consultant, Fixed Prosthodontics Department, Faculty of Dentistry, King Abdulaziz
University, Jeddah, Saudi Arabia
Alveolar ridge augmentation to set the stage for implant
placement is a common procedure in dental practice. There are many types of
bone graft that could be used for alveolar ridge augmentation including
autograft, allograft, and xenograft. The use of autograft to augment the ridge
has the advantage of avoiding immune rejection, disease transmission, and
faster healing period relative to the other augmentation methods. However,
careful clinical and radiographic examination is essential to minimize the
complication associated with harvesting the bone graft procedure.
There is some complication associated with chin autogenous
bone graft. For example chin ptosis, recession, and devitalizing the anterior
teeth and mandibular fracture. The application of the 5 mm rule is needed to
avoid complication. The procedure should be avoided if the plan is to harvest
large amount of bone from the donor site.
The ramus site should be considered if the clinician wants to augment
multiple implant sites.
Saudi Dental Journal
2007;19(SI)-Abstr.040
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